Polymorphisms in RAD51, XRCC2 and XRCC3 genes of the homologous recombination repair in colorectal cancer—a case control study
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چکیده
منابع مشابه
Polymorphisms of Homologous Recombination RAD51, RAD51B, XRCC2, and XRCC3 Genes and the Risk of Prostate Cancer
Genetic polymorphisms in DNA repair genes may induce individual variations in DNA repair capacity, which may in turn contribute to the risk of cancer developing. Homologous recombination repair (HRR) plays a critical role in maintaining chromosomal integrity and protecting against carcinogenic factors. The aim of the present study was to evaluate the relationship between prostate cancer risk an...
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15 صفحه اولPolymorphisms in DNA repair genes XRCC2 and XRCC3 risk of gastric cancer in Turkey.
We studied the prevalence of polymorphisms in genes XRCC2 and XRCC3 in stomach cancer patients who lived in North Eastern Turkey. A total of 61 cancer patients and 78 controls were included in this study. Single nucleotide changes were studied in XRCC2 and XRCC3 genes at locus Arg188His and Thr241Met. Blood samples were taken from the patients and controls, and DNA was isolated. The regions of ...
متن کاملPolymorphisms in RAD51, XRCC2, and XRCC3 are not related to breast cancer risk.
Highly penetrant, but rare, mutations in genes involved in double-strand break repair (i.e., BRCA1 and BRCA2) are associated with a risk for breast cancer of 40% to 65% by age 70 years (1, 2). Polymorphisms in other double-strand break repair genes are thought to contribute to the risk for the disease, either independently or through modifying the risk associated with rare mutations. This study...
متن کاملGenetics polymorphism in DNA repair genes by base excision repair pathway (XRCC1) and homologous recombination (XRCC2 and RAD51) and the risk of breast carcinoma in the Polish population.
Background : Several polymorphisms in the DNA repair gene have been extensively studied in the association with various human cancers such as breast cancer. Material and methods : We investigated the association of polymorphisms in the DNA repair genes XRCC1-Arg399Gln, XRCC2-Arg188His and RAD51-135G/C with the breast cancer risk. Genotypes were determined by PCR-RFLP assays in 220 patients with...
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ژورنال
عنوان ژورنال: Molecular Biology Reports
سال: 2010
ISSN: 0301-4851,1573-4978
DOI: 10.1007/s11033-010-0430-6